Article
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for AECOPD
April 1, 2025
Clinical question: Is high-flow nasal cannula oxygen therapy (HFNC) non-inferior to non-invasive ventilation (NIV) for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in...
Article
The CONVINCE Trial: No Reduction in Recurrent Vascular Events with Long-Term Colchicine Use After Ischemic Stroke
April 1, 2025
Clinical question: Does long-term colchicine use plus guideline-based care after ischemic stroke prevent recurrent vascular events? Background: According to the World Health Organization, stroke is...
Article
Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD
March 4, 2025
Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...
Article
Inhaled Amikacin in the First 72 Hours of Mechanical Ventilation Reduced the Incidence of VAP
January 1, 2025
Clinical question: Does inhaled amikacin reduce the incidence of ventilator-associated pneumonia (VAP) in critically ill patients? Background: VAP is a common and serious complication in patients on...
Article
Clinical Risk Score Predicts Arterial Thrombosis in Survivors of Intracranial Hemorrhage
January 1, 2025
Clinical question: Among survivors of hemorrhagic stroke, who is at high long-term risk of arterial thrombosis? Background: Patients who survive intracerebral hemorrhage (ICH) are at increased risk...
Article
Acute Cardiac Events are Common Among Adults 50 Years or Older Hospitalized with RSV and Associated with Severe Disease
December 2, 2024
Clinical question: How common are acute cardiac events among hospitalized older adults (50 years or older) with respiratory syncytial virus (RSV) infection and what are the associated risk...
Article
Gabapentinoids and Risk for Severe Exacerbation in COPD
December 2, 2024
Clinical question: Is gabapentinoid use associated with severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: The U.S. Food and Drug Administration issued a...
Article
Coding Corner: Spoonful of Sugar
October 1, 2024
A 46-year-old woman is admitted to the hospital with an exacerbation of chronic obstructive pulmonary disease (COPD) requiring intensification of her inhaler regimen, initiation of corticosteroids,...
Article
Comparing Outcomes of Targeted Reperfusion Therapy Versus Anticoagulation in Patients with Acute Intermediate-high-risk PE
October 1, 2024
Ms. Jang Clinical question: Do patients with acute intermediate-high-risk pulmonary embolism (PE) benefit more in terms of cardiac function from reperfusion therapy with conventional...
Article
DAPT Versus Alteplase for Patients With Minor Non-disabling Acute Ischemic Stroke
April 1, 2024
Clinical question: Is dual antiplatelet therapy (DAPT) non-inferior to intravenous thrombolysis in patients with minor non-disabling acute ischemic stroke? Background: Intravenous thrombolytics are...