Article
Incidence of Colorectal Cancer in Patients Diagnosed with PLA
November 1, 2024
Dr. Katsnelson Clinical question: Is there an association between pyogenic liver abscess (PLA) and subsequent incidence of diagnosed colorectal cancer (CRC) and if so, should early screening for...
Article
To RAASi or Not to RAASi, That is the Question
October 1, 2024
Clinical question: Should angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) be discontinued or continued in advanced chronic kidney disease (CKD)...
Article
ACLF Grade 3 Predicts Risk of Respiratory Failure with Terlipressin Use
October 1, 2024
Ms. Boyle Clinical question: Which risk factors predict new-onset respiratory failure during terlipressin use for the treatment of patients with rapidly deteriorating kidney function attributed...
Article
IV Sodium Thiosulphate for Calciphylaxis of CKD: A Systematic Review and Meta-analysis
August 1, 2024
Clinical question: Does IV sodium thiosulphate improve skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Background: Calciphylaxis, also called...
Article
DOACs Versus Warfarin Across the Spectrum of Kidney Function
April 1, 2024
Clinical question: How safe are direct oral anticoagulants (DOACs) to use in kidney dysfunction? Background: DOACs are increasingly being used in patients with kidney dysfunction. DOACs are cleared,...
Article
Associations of Apixaban Dose with Safety and Effectiveness Outcomes in Patients with Atrial Fibrillation and Severe CKD
April 1, 2024
Clinical question: Is the use of standard-dose apixaban based on creatinine criteria placing patients at higher risk of bleeding? Background: The U.S. Food and Drug Administration recommends...
Article
Risk for CKD Progression After AKI
February 1, 2024
Dr. Dalal Clinical question: Is acute kidney injury (AKI) associated with subsequent worsening of renal function trajectory in patients with chronic kidney disease (CKD)? Background: Prior...
Article
Apixaban Has Lower Risk of Bleeding Than Warfarin in ESKD
June 1, 2023
Dr. Leiner Clinical question: In patients with end-stage kidney disease (ESKD) and venous thromboembolism (VTE), does apixaban have a lower bleeding risk and VTE recurrence than...
Article
Early Initiation of Dialysis Improves Survival: To Start or Not to Start
March 1, 2023
Clinical question: What is the ideal estimated glomerular filtration rate (eGFR) at which to start dialysis in patients with advanced chronic kidney disease? Background: Uncertainty exists over the...
Article
Prediction of End-stage Kidney Disease Using Estimated Glomerular Filtration Rate With and Without Race
October 3, 2022
Dr. Choksi Clinical question: Does using old and new chronic kidney disease epidemiology collaboration (CKD-EPI) equations alone have a better predictive value for two-year incidence of end-stage...