Article
Antibiotic Overuse After Discharge: A Multi-hospital Cohort Study
March 1, 2023
Clinical question: Do patients need continued antibiotics after leaving the hospital? Background: Despite inpatient antimicrobial stewardship programs, studies suggest that up to half of antibiotics...
Article
Endoscopic Intervention Within 6-24 Hours for Non-variceal Upper GI Bleeding Leads to More Favorable Outcomes Compared to Early and Late Intervention
March 1, 2023
Clinical question: How does the timing of endoscopic intervention affect clinical outcomes in patients with acute non-variceal upper gastrointestinal (GI) bleeding? Background: Previous studies have...
Article
Duration of Abstinence from Alcohol Prior to Liver Transplantation Does Not Lead to Increased Survival in Patients with Alcohol-related Liver Disease
March 1, 2023
Clinical question: How does the duration of abstinence from alcohol affect patient survival, allograft survival, and relapse-free survival in patients undergoing liver transplantation? Background:...
Article
MELD 3.0 is a More Equitable and Accurate Predictor of Mortality in Patients with Cirrhosis than MELD-Na
March 1, 2023
Clinical question: How does Model for End-Stage Liver Disease (MELD) 3.0 compare to MELD-Na in regard to liver transplant waitlist mortality? Background: The MELD-Na scoring system has been proven...
Article
Acetaminophen Rises Systolic Blood Pressure in Those with Hypertension
March 1, 2023
Clinical question: Does regular intake of acetaminophen cause an increase in blood pressure? Background: Acetaminophen is one of the most commonly used analgesics in the world. Because of its...
Article
Early Initiation of Dialysis Improves Survival: To Start or Not to Start
March 1, 2023
Clinical question: What is the ideal estimated glomerular filtration rate (eGFR) at which to start dialysis in patients with advanced chronic kidney disease? Background: Uncertainty exists over the...
Article
Bolus IV 0.9% Saline Leads to Interstitial Permeability Pulmonary Edema in Healthy Volunteers
March 1, 2023
Clinical question: Can intravenous fluid (IVF) administration cause direct lung injury independent of cardiogenic overload? Background: Bolus IVF therapy is a central component to managing...
Article
Effectiveness of Oxycodone Hydrochloride vs. Combination Acetaminophen and Codeine for Subacute Pain After Fractures Managed Surgically: A Randomized Controlled Trial
March 1, 2023
Clinical question: Do less potent opioids suffice for adequate pain control for patients with surgically managed fractures? Background: For post-surgical pain management at time of discharge,...
Article
Nutritional Support Improves Mortality in Frail, Elderly Patients
March 1, 2023
Clinical question: Is there a mortality benefit to optimizing nutritional status for malnourished patients with age-related frailty? Background: Age-related frailty syndrome has been associated with...
Article
Mirtazapine Administration Associated with Moderate Risk of Hyponatremia
March 1, 2023
Clinical question: What is the incidence of hyponatremia in patients treated with mirtazapine? Background: The development of hyponatremia has been associated with selective serotonin inhibitors and...