Article
Semaglutide in Patients with HFpEF and Obesity
April 1, 2024
Clinical question: Does treatment with semaglutide lead to a reduction in symptoms and physical limitations and improve exercise function in patients with heart failure with preserved ejection...
Article
VTEs and Their Effects on Patients with AE-COPD
April 1, 2024
Clinical question: How common are venous thromboembolisms (VTEs) in patients presenting with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and what is the effect on prognosis,...
Article
Risk and Benefit of Secondary Prevention with Aspirin Versus P2Y12 Inhibitor in CAD Patients
April 1, 2024
Clinical question: In patients with coronary artery disease (CAD), what is the difference in risk and benefit between secondary prevention with aspirin (ASA) versus a P2Y12 inhibitor? Background:...
Article
Cefepime Versus Piperacillin-tazobactam in Adults Hospitalized with Acute Infection
April 1, 2024
Clinical question: Are there increased adverse outcomes with the utilization of cefepime or piperacillin-tazobactam? Background: Hospitalists frequently prescribe cefepime or piperacillin-tazobactam...
Article
Time to Benefit of SGLT-2 Inhibitors Among Patients with HF
April 1, 2024
Clinical question: What is the time to benefit for patients with heart failure (HF) and prescribed a sodium-glucose cotransporter-2 (SGLT-2) inhibitor? Background: SGLT-2 inhibitors are an effective...
Article
Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum
April 1, 2024
Clinical question: Can serum procalcitonin reliably detect bloodstream infections upon hospital admission? Background: Hospitalists frequently manage patients with bacteremia, which is often...
Article
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
April 1, 2024
Clinical question: Does pitavastatin decrease major adverse cardiovascular events (MACEs) in patients infected by the human immunodeficiency virus (HIV) who are on antiretroviral therapy (ART) and...
Article
DAPT Versus Alteplase for Patients With Minor Non-disabling Acute Ischemic Stroke
April 1, 2024
Clinical question: Is dual antiplatelet therapy (DAPT) non-inferior to intravenous thrombolysis in patients with minor non-disabling acute ischemic stroke? Background: Intravenous thrombolytics are...
Article
Early Restrictive or Liberal Fluid Management for Sepsis-induced Hypotension
April 1, 2024
Clinical question: What’s the effect of restrictive versus liberal fluid resuscitation strategies in sepsis-induced hypotension on 90-day mortality? Background: Intravenous fluid resuscitation is...
Article
Moderate-intensity Statin With Ezetimibe Combination Therapy Versus High-intensity Statin Monotherapy in Patients at Very High Risk of ASCVD
April 1, 2024
Clinical question: Can you use a moderate-intensity statin with ezetimibe combination therapy for very high-risk (VHR) patients with ASCVD? Background: The ACC/AHA guidelines recommend the use of...