Article
Weighing Benefits and Risks of Indefinite Anticoagulation in First Unprovoked VTE
October 2, 2023
Clinical question: Is indefinite anticoagulation beneficial for patients with a first unprovoked venous thromboembolism (VTE) after initial treatment? Dr. Sheikh Background: VTE is a chronic,...
Article
Pitavastatin and Cardiovascular Disease Prevention in HIV Patients
October 2, 2023
Clinical question: Does pitavastatin reduce the risk of cardiovascular disease in human immunodeficiency virus (HIV)-infected individuals? Dr. Sheikh Background: Individuals with HIV infection...
Article
No Difference Between Liberal Versus Strict Perioperative BP Management in Non-cardiac Surgery
October 2, 2023
Clinical question: In patients on antihypertensive medications (AHMs) such as angiotensin-converting-enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) undergoing inpatient...
Article
DAPT Non-inferior to Alteplase for Minor AIS
October 2, 2023
Clinical question: Is dual antiplatelet therapy (DAPT) non-inferior to intravenous (IV) thrombolysis in patients with minor non-disabling acute ischemic strokes (AIS)? Dr....
Article
Intensive BP Control with PO or IV Harmful in Hospitalized Older Adults
October 2, 2023
Clinical question: How do clinical outcomes compare between patients with asymptomatic hypertension treated intensively versus not while hospitalized? Dr. Richardson Background: While the...
Article
Delayed Antibiotics in Suspected Sepsis Increase Shock Risk and Mortality
October 2, 2023
Clinical question: Does the time to first antibiotics affect the risk of progression to septic shock? Dr. Richardson Background: The Surviving Sepsis Campaign emphasized early infection...
Article
P2Y12 Inhibitor Monotherapy After 1-3 Months of DAPT Reduces Major Bleeding Risk Without Increasing Ischemic Risk After Complex PCI
October 2, 2023
Clinical question: Does P2Y12 inhibitor monotherapy after one to three months of dual antiplatelet therapy (DAPT) improve clinical decrease in major bleeding risk without increasing ischemic risk in...
Article
Early Restrictive Fluid Strategy Didn’t Lower Mortality for Sepsis-induced Hypotension
September 1, 2023
Dr. Klein Clinical question: Does a restrictive fluid strategy within the first 24 hours improve all-cause mortality among patients with sepsis-induced hypotension? Background: There are limited...
Article
Sustained Reduction in Lab Ordering After Implementing Mindful Ordering Initiatives
September 1, 2023
Dr. Mohoney Clinical question: Do perceptions of mindful laboratory test ordering and number of labs ordered change after resident-focused training and optimization of electronic medical record...
Article
Prioritizing Discharging Patients While Rounding Didn’t Result in Earlier Discharge Times or Reduced LOS
September 1, 2023
Dr. Klein Clinical question: Does a physician rounding style prioritizing discharging patients lead to earlier discharges or reduced length of stay (LOS)? Background: Delayed discharges can...