Article
Duration of Abstinence from Alcohol Prior to Liver Transplantation Does Not Lead to Increased Survival in Patients with Alcohol-related Liver Disease
March 1, 2023
Clinical question: How does the duration of abstinence from alcohol affect patient survival, allograft survival, and relapse-free survival in patients undergoing liver transplantation? Background:...
Article
MELD 3.0 is a More Equitable and Accurate Predictor of Mortality in Patients with Cirrhosis than MELD-Na
March 1, 2023
Clinical question: How does Model for End-Stage Liver Disease (MELD) 3.0 compare to MELD-Na in regard to liver transplant waitlist mortality? Background: The MELD-Na scoring system has been proven...
Article
Acetaminophen Rises Systolic Blood Pressure in Those with Hypertension
March 1, 2023
Clinical question: Does regular intake of acetaminophen cause an increase in blood pressure? Background: Acetaminophen is one of the most commonly used analgesics in the world. Because of its...
Article
Early Initiation of Dialysis Improves Survival: To Start or Not to Start
March 1, 2023
Clinical question: What is the ideal estimated glomerular filtration rate (eGFR) at which to start dialysis in patients with advanced chronic kidney disease? Background: Uncertainty exists over the...
Article
Bolus IV 0.9% Saline Leads to Interstitial Permeability Pulmonary Edema in Healthy Volunteers
March 1, 2023
Clinical question: Can intravenous fluid (IVF) administration cause direct lung injury independent of cardiogenic overload? Background: Bolus IVF therapy is a central component to managing...
Article
Effectiveness of Oxycodone Hydrochloride vs. Combination Acetaminophen and Codeine for Subacute Pain After Fractures Managed Surgically: A Randomized Controlled Trial
March 1, 2023
Clinical question: Do less potent opioids suffice for adequate pain control for patients with surgically managed fractures? Background: For post-surgical pain management at time of discharge,...
Article
Nutritional Support Improves Mortality in Frail, Elderly Patients
March 1, 2023
Clinical question: Is there a mortality benefit to optimizing nutritional status for malnourished patients with age-related frailty? Background: Age-related frailty syndrome has been associated with...
Article
Mirtazapine Administration Associated with Moderate Risk of Hyponatremia
March 1, 2023
Clinical question: What is the incidence of hyponatremia in patients treated with mirtazapine? Background: The development of hyponatremia has been associated with selective serotonin inhibitors and...
Article
Reflections Forward
March 1, 2023
Rising costs of care. Decreasing access to care. Inequities in access to quality care. Inequities in care. Systemic bias and racism. Polarizing politics. Decreasing resources. Aging systems. Aging...
Article
The Big Tent of Health Care Must be Bigger
March 1, 2023
As I feared in last year’s Editor’s Column, this past year has seen one crisis merge into successive crises, making our waking lives a nightmarish fever dream. Just when we thought we were...