Article
Early Versus Later Anticoagulation for Stroke with Atrial Fibrillation
October 1, 2024
Mr. Gegg-Mitchell Clinical question: What is the safety and efficacy of early compared with later initiation of direct oral anticoagulants (DOACs) in patients with atrial fibrillation and...
Article
Comparing Outcomes of Targeted Reperfusion Therapy Versus Anticoagulation in Patients with Acute Intermediate-high-risk PE
October 1, 2024
Ms. Jang Clinical question: Do patients with acute intermediate-high-risk pulmonary embolism (PE) benefit more in terms of cardiac function from reperfusion therapy with conventional...
Article
To RAASi or Not to RAASi, That is the Question
October 1, 2024
Clinical question: Should angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) be discontinued or continued in advanced chronic kidney disease (CKD)...
Article
Lactated Ringers in the First 24 Hours of Hospitalization May Improve Acute Pancreatitis Severity
October 1, 2024
Ms. Thuy Dam Clinical question: Does the administration of lactated ringers (LR) in the first 24 hours of admission reduce the risk of more severe forms of acute pancreatitis compared to normal...
Article
ASCO Guideline for the Use of Opioids for Adults with Cancer or Cancer Treatment
October 1, 2024
Ms. Parikh Clinical question: What are expert recommendations for the use of opioids for adults with pain from cancer? Background: Pain is a common consequence of cancer and cancer treatment....
Article
ACLF Grade 3 Predicts Risk of Respiratory Failure with Terlipressin Use
October 1, 2024
Ms. Boyle Clinical question: Which risk factors predict new-onset respiratory failure during terlipressin use for the treatment of patients with rapidly deteriorating kidney function attributed...
Article
The STRONG-HF Trial: Evaluating the Safety, Tolerability, and Effectiveness of Up-titrating GDMT in Acute Heart Failure
August 1, 2024
Clinical question: Does rapid up-titration of guideline-directed medical therapies (GDMT) following admission for acute heart failure improve patient outcomes? Background: GDMT provides...
Article
No Difference in Safety or Mortality with Restrictive Versus Liberal Fluid Resuscitation Strategy for Ongoing Resuscitation in ICU Patients with Septic Shock
August 1, 2024
Clinical question: Are there safety or mortality benefits to the use of a more restrictive versus liberal IV fluid strategy for ongoing IV fluid resuscitation in critically ill patients with septic...
Article
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
August 1, 2024
Clinical question: Is the treatment strategy with ticagrelor superior to prasugrel in acute coronary syndrome (ACS) with planned invasive evaluation at one year? Background: Dual antiplatelet...
Article
IV Sodium Thiosulphate for Calciphylaxis of CKD: A Systematic Review and Meta-analysis
August 1, 2024
Clinical question: Does IV sodium thiosulphate improve skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Background: Calciphylaxis, also called...