Article
Lactated Ringer’s No Different Than Normal Saline for Routine Inpatient IV Fluid Administration
February 2, 2026
CLINICAL QUESTION: In hospitalized patients, does IV administration of lactated Ringer’s solution (LR) reduce mortality or readmission compared to normal saline (NS)? BACKGROUND: Crystalloid fluid...
Article
FMT is a Noninferior Treatment Option for Primary CDI
February 2, 2026
CLINICAL QUESTION: Is fecal microbiota transplantation (FMT) safe and efficacious in the treatment of primary Clostridioides difficile infection (CDI)? BACKGROUND: FMT is currently recommended for...
Article
LLMs and Physicians Generate Comparable Hospital Discharge Summaries
February 2, 2026
CLINICAL QUESTION: Can large language models (LLMs) produce hospital discharge summary narratives comparable in quality and safety to those written by physicians? BACKGROUND: High-quality hospital...
Article
Navigational Bronchoscopy is Diagnostically Non-Inferior Compared to Transthoracic Needle Biopsy in Evaluation of Lung Nodules
February 2, 2026
CLINICAL QUESTION: In the evaluation of peripheral lung nodules, how does navigational bronchoscopy compare to transthoracic needle biopsy regarding diagnostic accuracy and procedural...
Article
Adding Budesonide to Albuterol Rescue Therapy in Patients with Mild Asthma Decreases Severe Exacerbations
February 2, 2026
CLINICAL QUESTION: Is as-needed albuterol-budesonide superior to albuterol alone in patients with mild asthma? BACKGROUND: Although patients with mild asthma are often considered low risk, they...
Article
The cogPOISE-3 Trial: No Changes in Neurocognitive Outcomes Associated with Perioperative Hypotension Avoidance Versus Hypertension Avoidance
February 2, 2026
CLINICAL QUESTION: Does perioperative hypotension avoidance versus hypertension avoidance carry an increased risk of postoperative delirium or cognitive decline? BACKGROUND: There is concern that...
Article
Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes
February 2, 2026
CLINICAL QUESTION: Does oral semaglutide decrease major cardiovascular events in patients with type 2 diabetes and cardiovascular disease and/or chronic kidney disease? BACKGROUND: Approximately 828...
Article
Discordant Pleural Exudates Are Common and Have a Different Diagnostic Pattern Than Concordant Pleural Exudates
February 2, 2026
CLINICAL QUESTION: How common are discordant pleural fluid exudates, and do they have different diagnostic patterns compared to concordant pleural fluid exudates? BACKGROUND: Pleural effusions are...
Article
CPOE Prompts Reduce Use of Empiric Extended-Spectrum Antibiotics for SSTIs Without Increasing ICU Admissions or Hospital LOS
February 2, 2026
CLINICAL QUESTION: Can computerized provider order entry (CPOE) prompts safely reduce empiric extended-spectrum antibiotic use for noncritically ill, hospitalized patients with skin and soft tissue...
Article
Oral Anticoagulation and Risk of Adverse Clinical Outcomes in VTE
February 2, 2026
CLINICAL QUESTION: How do the three most prescribed oral anticoagulants compare in regard to venous thromboembolism (VTE) recurrence, prevention, and major bleeding? BACKGROUND: Oral anticoagulants...