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Prednisolone, Pentoxifylline, and Survival of Patients with Severe Alcoholic Hepatitis
October 28, 2014
Clinical question: Does the addition of pentoxifylline to prednisolone improve six-month mortality compared to prednisolone alone in patients with severe alcoholic hepatitis? Background: Prednisolone improves liver function and reduces inflammation in patients with alcoholic hepatitis.
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Turning for Ulcer Reduction: A Multi-Site Randomized Clinical Trial in Nursing Homes
October 28, 2014
Clinical question: Is there a difference between repositioning intervals of two, three, or four hours in pressure ulcer formation in nursing home residents on high-density foam mattresses? Background: Pressure ulcer formation in nursing home residents is a common problem.
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Antibiotic Resistance Threats in the United States, 2013
October 28, 2014
Clinical question: What antibiotic-resistant bacteria are the greatest threats for the next 10 years? Background: Two million people suffer antibiotic-resistant infections yearly, and 23,000 die each year as a result.
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Once-Weekly Antibiotic Might Be Effective for Treatment of Acute Bacterial Skin Infections
October 27, 2014
Research suggests intravenous dalbavancin similarly efficacious to intravenous vancomycin
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Holding Chambers (Spacers) vs. Nebulizers for Acute Asthma
October 27, 2014
Clinical question: Are beta-2 agonists as effective when administered through a holding chamber (spacer) as they are when administered by a nebulizer? Background: During an acute asthma attack, beta-2 agonists must be delivered to the peripheral airways.
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Long-Term Cognitive Impairment after Critical Illness
October 27, 2014
Clinical question: Are a longer duration of delirium and higher doses of sedatives associated with cognitive impairment in the hospital? Background: Survivors of critical illness are at risk for prolonged cognitive dysfunction.
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Endoscopic vs. Surgical Cystogastrostomy for Pancreatic Pseudocyst Drainage
October 27, 2014
Clinical question: How does endoscopic cystogastrostomy for pancreatic pseudocyst drainage compare to the standard surgical approach? Background: Pancreatic pseudocysts are a common complication of pancreatitis and necessitate decompression when they are accompanied by pain, infection, or obstruc
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Single vs. Dual Antiplatelet Therapy after Stroke
October 27, 2014
Clinical question: Is dual antiplatelet therapy more beneficial or harmful than monotherapy after ischemic stroke? Background: It is recommended that patients with ischemic stroke or transient ischemic attack (TIA) receive lifelong antiplatelet therapy; however, there have been insufficient studi
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Four Things HMGs Should Do To Prepare for Ebola
October 27, 2014
Dallas-based hospitalist recommends ways to spot patients with potential infection, prevent disease spread
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New Oral Anticoagulants Increase GI Bleed Risk
October 27, 2014
Clinical question: Do thrombin and factor Xa inhibitors increase the risk of gastrointestinal (GI) bleeding when compared to vitamin K antagonists and heparins? Background: New oral anticoagulants (thrombin and factor Xa inhibitors) are available and being used with increased frequency due to equ
