News
Treatment of Patients with Atrial Fibrillation, Low CHA2DS2-VASc Scores
June 8, 2015
Clinical question: Is anticoagulation beneficial for patients with atrial fibrillation (Afib) and low CHA2DS2-VASc score (0 for men, 1 for women) or for those with one additional stroke risk factor? Background: Guidelines nearly universally recommend anticoagulation for patients with a CHA2DS2-VA
News
Research Review: Ticagrelor for Post-Myocardial Infarction
June 8, 2015
Clinical question: Is ticagrelor for secondary prevention indicated for more than one year after myocardial infarction (MI)? Background: The efficacy and safety of ticagrelor combined with low-dose aspirin more than one year after MI for secondary prevention has not previously been established.
News
How Should a Patient with Pulmonary Hypertension Be Evaluated, Managed?
June 1, 2015
Case A 62-year-old female with no significant past medical history presents with three weeks of progressive dyspnea on exertion and bilateral lower extremity edema. Family members report that the patient often snores and “gasps for air” during sleep.
News
D-Dimer Not Reliable Marker to Stop Anticoagulation Therapy
May 5, 2015
Clinical question: In patients with a first unprovoked VTE, is it safe to use a normalized D-dimer test to stop anticoagulation therapy? Background: The risk of VTE recurrence after stopping anticoagulation is higher in patients who have elevated D-dimer levels after treatment.
News
Noninvasive Ventilation Improves Outcomes for COPD Inpatients
May 5, 2015
Clinical question: Do patients hospitalized with acute COPD exacerbations have improved outcomes with noninvasive ventilation (NIV) compared to those treated with invasive mechanical ventilation (IMV)? Background: Previous studies have shown that in select patients, NIV has a mortality benefit ov
News
Bova Risk Model Predicts 30-Day Pulmonary Embolism-Related Complications
May 5, 2015
Clinical question: Can the Bova risk model stratify patients with acute PE into stages of increasing risk for 30-day pulmonary embolism (PE)-related complications? Background: The Bova score is based on four variables assessed at the time of PE diagnosis: heart rate, systolic blood pressure, card
News
Intracranial Bleeding Risk for Head Injury Patients on Warfarin
May 5, 2015
High bleeding rates reported for patients taking warfarin after minor, minimal head injuries
News
Enriched Nutritional Formulas Help Heal Pressure Ulcers
May 5, 2015
Arginine, zinc, antioxidant-supplemented formulas improve healing in malnourished patients
News
High-Volume Hospitals Have Higher Readmission Rates
May 5, 2015
Clinical question: Is there an association between hospital volume and hospital readmission rates? Background: There is an established association between high patient volume and reduced complications or mortality after surgical procedures; however, readmission represents a different type of qual
News
Hospital Testing Overuse Done to Reassure Patients, Families
May 5, 2015
Clinical Question: What is the extent of, and factors associated with, testing overuse in U.S.