Summary
Adverse drug reactions can present clinically in many different ways, and, indeed, these reactions have deposed syphilis and tuberculosis as the mimic of disease. Many adverse drug reactions are mild, but others can be severe and, occasionally, life-threatening. This variability in manifestations means clinicians always have to consider that the drug may be the cause of the patient’s symptoms. TH
Johnson is a medical student at the Kansas City University of Medicine and Biosciences, Kansas City, Mo. Dr. Egger is a consultant in general internal medicine at the Mayo Clinic, Rochester, Minn.
References
- Byrd JB, Adam A, Brown NJ. Angiotensin-converting enzyme inhibitor-associated angioedema. Immunol Allergy Clin North Am. 2006;26(4):725-737.
- Kostis JB, Kim HJ, Rusnak J, et al. Incidence and characteristics of angioedema associated with enalapril. Arch Intern Med. 2005 Jul;165(14):1637-1642.
- Kostis JB, Packer M, Black HR, et al. Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial. Am J Hypertens. 2004 Feb;17(2):103-111.
- Kaplan AP, Greaves MW. Angioedema. J Am Acad Dermatol. 2005;53:373-388.
- Agostoni A, Cicardi M, Cugno M, et al. Angioedema due to angiotensin-converting enzyme inhibitors. Immunopharmacology. 1999;44:21-25.
- Molinaro G, Cugno M, Perez M, et al. Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin. J Pharmacol Exp Ther. 2002;303:232-237.
- Ward KE, Hume AL. Olmesartan (benicar) for hypertension. Am Fam Physician. 2005;72:673-674.